Search results for "Stratum granulosum"

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The α and β Subunits of the Metalloprotease Meprin Are Expressed in Separate Layers of Human Epidermis, Revealing Different Functions in Keratinocyte…

2007

The zinc endopeptidase meprin (EC 3.4.24.18) is expressed in brush border membranes of intestine and kidney tubules, intestinal leukocytes, and certain cancer cells, suggesting a role in epithelial differentiation and cell migration. Here we show by RT-PCR and immunoblotting that meprin is also expressed in human skin. As visualized by immunohistochemistry, the two meprin subunits are localized in separate cell layers of the human epidermis. Meprin alpha is expressed in the stratum basale, whereas meprin beta is found in cells of the stratum granulosum just beneath the stratum corneum. In hyperproliferative epidermis such as in psoriasis vulgaris, meprin alpha showed a marked shift of expre…

KeratinocytesPathologymedicine.medical_specialtyCell SurvivalCellular differentiationStratum granulosumHuman skinCell CountDermatologyBiologyBiochemistryCell Line03 medical and health sciencesmedicineHumansMolecular Biology030304 developmental biologyCell Proliferation0303 health sciencesMeprin AEpidermis (botany)integumentary systemCell growth030302 biochemistry & molecular biologyMetalloendopeptidasesCell DifferentiationCell BiologyCell biologymedicine.anatomical_structureEpidermal CellsGene Expression RegulationKallikreinsEpidermisKeratinocyteStratum basaleJournal of Investigative Dermatology

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